Pediatric Liver Transplant Cost in India

Liver Transplant Success Rate in India

A liver transplant is a sophisticated procedure used to swap out a diseased liver for a healthy liver from another person.

A surgical procedure used to treat liver failure in children is known as a paediatric liver transplant. The liver is crucial for both digestion of food and the detoxification of the body of all toxins.

Your child may develop liver failure, a condition that poses a serious risk to their life if their liver stops functioning. Liver failure results from the liver’s inability to filter harmful substances from the blood.

How much does a Paediatric Liver Transplant Cost in India?

Paediatric liver transplants in India with standard complications will cost approximately USD 25,000, which is one-tenth of the cost as compared to the world’s best centres with quality being at par.

The cost of an organ transplant is influenced by a few things, including:

  • The length of the patient’s hospital stay following surgery is based on the patient’s clinical condition.
  • Co-morbidities that are associated with the transplant may slow the recovery process.
  • If the liver needs to be brought from another Indian city, there will be organ recovery and transport costs (in the case of DDLT).

The procedure for a paediatric liver transplant in India is somewhat similar to an adult liver transplant. However, because children with the liver disease face particular difficulties, they will gain from the extensive training of transplant surgeons in India, who have performed both paediatric and adult liver transplants.

Due to the smaller diameter of the vessels, paediatric liver transplants present unique challenges that call for higher surgical skill, specialised paediatric intensive care, and typically a longer length of postoperative hospital stay.

  • In India, a liver transplant requires a minimum of two months of stay.
  • Surgery can only be performed after receiving approval from the Authorization Committee and is governed by an Act that applies to all solid organ transplants in India.
  • If all statutory requirements are met, it takes a minimum of 15 days to request approval from the committee.
  • After leaving the hospital, it is advised that you stay for a month to observe how your new liver is functioning before departing for your country of origin.
  • If the donation went smoothly, the donor can fly back to their home country 10 days after the procedure.

Patient Testimonial: Shakila Khan from Trinidad and Tobago got successful Liver Transplant in India

Patient Shakila khan and her daughter are sharing their experience about how Dr. Surbhi and Lyfboat’s team helped them with all the logistics in India while their stay in India.

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What is the success rate of paediatric liver transplants?

  • In India, the number of liver transplants has increased dramatically over the past ten years; with more than, 135 centres performing between 1500 and 2000 transplants annually, 10% of which are paediatric.
  • India is now a significant regional liver transplant hub in South and South-East Asia with a survival rate exceeding 90%.
  • The list of indications has grown to include an increasing number of metabolic disorders based on the liver that may or may not result in liver disease.
  • With the help of cutting-edge microvascular techniques, recipients who were previously thought to be non-transplantable, such as those who already had portal vein thrombosis, can be successfully managed.
  • There has been a steep rise in the number of potential donors. Crowdfunding and increased philanthropic efforts are helping to alleviate financial constraints.

Causes of Paediatric Liver Transplant

As primary care physicians become more aware of liver diseases and as various diagnostic modalities advance and become more widely available, there is an increase in the diagnosis of liver diseases in children.

The treatment for many paediatric liver diseases frequently includes liver transplantation. The following are a few common conditions that affect children’s livers:

  • Cholestatic liver disease:
  • Biliary atresia
  • Progressive Familial Intrahepatic Cholestasis
  • Alagille Syndrome- genetic liver diseases
  • Metabolic liver disease:
  • Wilson disease (including fulminant Wilson disease)
  • Hyperoxaluria
  • Disorders of amino acid metabolism (including urea cycle defects)
  • Alpha 1 antitrypsin deficiency- an inherited condition that raises the risk for liver disease
  • Liver tumours:
  • Hepatoblastoma
  • Hepatocellular carcinoma
  • Budd Chiari Syndrome
  • Acute Liver Failure
  • Sudden or acute liver failure. It can happen due to various reasons like viral infections, the effect of an autoimmune disease, unknown causes, or an overdose of medicine.
  • Liver diseases like tyrosinemia
  • Cholestatic disorders

What are the types of pediatric liver transplantation in India?

An operation called a liver transplant replaces a diseased liver with a healthy liver from an organ donor.

There are two types of liver transplantation process:

  • Cadaveric Liver transplantation is where someone who recently passed away could provide a new organ. It’s also known as a “deceased donor liver transplant” (DDLT).
  • Living-related liver transplantation is where a new liver is from an adult who donates a portion of their own. It is also referred to as a “living donor liver transplant” (LDLT). The liver that is still in the living donor regenerates.
  • Within a few months of the procedure, it regains its normal size and functionality.
  • Candidates for living donation must be in sound physical and mental condition. To determine compatibility with the recipient, they must undergo medical examinations, including blood tests.

The pool of organ donors, available is increased by providing alternatives to the standard whole liver transplant and bringing the child to transplant quickly to create the best outcome for your child. Other options for pediatric liver transplantation may include:

  • Full graft liver: Also called a whole liver transplant, the entire liver from a deceased donor is placed in the child.
  • Split liver: A large liver is split and shared between the child and another child or small adult who is also awaiting a transplant.
  • Reduced-size liver: A liver from a larger donor is trimmed to fit the child.
  • ABO-incompatible: With this cutting-edge transplant, your child’s blood type doesn’t have to exactly match the donors in order for us to move your child up the list and perform a life-saving transplant right away.
  • Combined solid organ transplant: which is also known as a multiorgan transplant, a critically ill child with complex needs receives a liver transplant in addition to a heart, lung, and/or kidney.

Living-Donor Transplant Advantages

Such liver transplants are carried out by close relatives in order to save the life of a child who requires a liver transplant but cannot wait any longer on the waiting list. Other advantages include:

  • There is no waiting for a donor from the transplant list to become available.
  • Surgery for liver transplantation can be organised efficiently and on time.
  • Donors (the family) can take comfort in the fact that they made a significant difference in the child’s life.
  • The fact that transplant recipients are receiving a portion of a healthy donor’s liver may have an impact on their long-term prognosis.

Conditions to Donate a Liver

The liver donation, in which a portion of a healthy person’s liver is surgically removed and used for transplant, is extremely safe.

The donor spends 7–10 days in the hospital, then recovers at home for 2–3 weeks before returning to his pre-surgery condition.

Within two to three weeks, the liver regenerates (i.e., grows back to its normal size).

The living liver donor must be between the ages of 18 and 55, be a member of a healthy, happy family, weigh between 50 and 85 kg, be in good health overall, and not be overweight or obese (as these conditions are associated with fatty livers that may not function properly in the recipient), and have blood group “O” (universal donors) or the same as the patient.

A healthy donor must have a BMI less than or equal to 32, should not be engaged in active ongoing drug or substance use, should have an unselfish desire to contribute to another person’s life in a healthy way should be in general good health with no history of:

  • Liver disease, including cirrhosis and hepatitis.
  • Significant diseases involving the other organs: lungs, kidneys, and heart.
  • Pulmonary hypertension.
  • HIV.
  • Active malignant cancers.

Process of Pre-Transplant Evaluation:

This involves examining each body system for optimal performance and the presence of unexpected illness. The immunisation records for your child will be examined. Some vaccines cannot be administered after transplantation, while others might not be as effective.

Additionally, a thorough nutritional analysis is carried out. Several tests are run, including:

  • Urine and blood tests in laboratories
  • ECG: electrocardiogram
  • CT scan of the liver and blood vessels performed on the chest

The Transplant Evaluation Process

Before kids can be added to the transplant waiting list, they must go through a long list of evaluation steps and procedures. The transplant centre staff will perform a variety of tests, such as:

  • Blood tests: Only blood group matching is necessary for liver transplants. However, additional blood tests are also carried out to detect any minor issues with other systems in both the child and the donor.
  • Tests for diagnosis: These tests for diagnosis examine the liver and overall health of a child. Dental exams, X-rays, ultrasounds, liver biopsies, CT scans, echocardiograms, and other tests may be among them.
  • Psychological and social evaluation: If the child is old enough to comprehend what is happening and how it will affect them forever (since they will need to take lifelong medication, etc.), these tests are performed on them.

How can Lyfboat assist you getting Pediatric Liver Transplantation in India?

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Risks of a Liver Transplant for a Child

A few of the risk factors from liver transplant surgery may be –

  • The immune system of the body rejects the new liver. It is a very typical occurrence that follows surgery. The immune system perceives the new liver organ as a threat after it is implanted in the child’s body and begins to attack it.
  • Blood loss
  • Illness
  • Obstructions in the new liver’s blood vessels
  • Bile leakage or clogged bile ducts
  • The new liver not functioning for a brief period of time after surgery.

The child needs to take immunosuppressants, which are anti-rejection medications, to help their immune system accept the new organ. These drugs lessen the immune system’s assault on the newly developed liver.

These medications must be administered to the child for the rest of their life. The doses are nevertheless reduced to the absolute minimum.

Life After the Pediatric Liver Transplant

It takes a lifetime to adjust to having a liver transplant. For the immune system to stop attacking the new liver, the child will need to take anti-rejection medications.

To avoid the anti-rejection medications’ side effects, additional medications must be administered. Infections are among these negative effects. the child and the family need to stay in touch with the transplant team frequently.

When they are old enough, a kid needs to learn everything there is to know about anti-rejection medications and how they work.

The signs of rejection and everything else the family has learned will need to be taught to the child. This is crucial so that the child can one day take care of themselves without assistance.

Frequently Asked Questions

Q. When is a liver transplant necessary for your child?

If the child has severe liver issues that are unresponsive to medication and may prevent survival without a new liver, a liver transplant procedure may be an option. Biliary atresia is one of the conditions that necessitate a child’s liver transplant the most frequently. In this condition, the liver is unable to remove bile from the body. Additional conditions include:

Liver failure that is sudden or acute. It can occur for a number of reasons, including viral infections, the results of an autoimmune disease, unidentified causes, or a medication overdose.

  • Liver conditions such as Wilson’s disease and tyrosinemia
  • Alagille syndrome and cholestatic disorders are examples of genetic liver disorders
  • Hepatic cancers such as hepatoblastoma
  • Liver cancer
  • Budd-Chiari disease
  • Unhealthy alpha-1 antitrypsin is a genetic disorder.

Q. What happens during the evaluation stage of a child’s liver transplant?

The child will need to undergo an evaluation process before becoming healthy enough for a liver transplant. There are numerous tests conducted, including:

  • Diagnostic procedures to check the general and liver health of the child
  • Evaluation of the child’s mental health and social development as well as that of his or her/their family
  • Chest X-ray, echo, CT scan, and colour Doppler.

These examinations will assist in determining whether or not the child qualifies for a liver transplant. A child may not be able to receive a transplant in some circumstances, including:

  • If an ongoing infection or active infection is present in your child
  • Irreparable brain injury
  • If the child has heart issues (which can be managed medically or surgically),
  • If the child has a serious condition in another part of their body, the transplant may not help.

Q. Can infants and newborns receive liver transplants?

Liver transplant surgeries are safe for infants and newborns, but they come with a few extra risks.

  • To help the baby grow as much as possible before the transplant, the doctor or liver transplant hospital may stabilise the disease and slow its progression.
  • There are fewer chances of complications before or after the transplant if the baby is large and healthy.
  • If more waiting is not an option, liver transplantation can still be done at this age.

Q. What conditions must be met for the child to receive a liver donation?

The suitability of a potential donor to donate a liver to a child depends on a number of factors. Among them are:

  • The donor’s age should range from 18 to 55 years old.
  • The donor’s physical and mental health should be good.
  • The donor’s blood type needs to match your child’s blood type.

Q. What paperwork is required in India for organ transplants?

  • The Transplantation of Human Organs Act, of 1994 is the legal framework in India that governs solid organ transplantation. This law was passed to stop medical ethics and the sale of human organs.
  • According to the Act, all significant Indian hospitals have statutory licences to perform human organ transplants.
  • This act only permits transplants when the donor and recipient meet specific requirements, which are overseen by the transplant authorization committee established by the Indian government.

If the Authorization Committee discovers a discrepancy in your documents, it may decide not to grant permission for the organ transplant surgery.

Q. Who is the close relative donor?

It only refers to the donor’s grandparents, parents, spouse, siblings, children, and grandchildren. A close relative donor would refer to the husband or wife in the case of married donors.

Q. Who is the first-degree donor?

Grandparents, parents, kids, siblings, and grandchildren are the only relations in the first degree.

Q. Who is a distant relative or unrelated donor?

Distant relatives include cousins, in-laws, nieces, nephews, and brothers or sisters’ in-law. All other donors fall under the category of unrelated donors.

According to the Transplantation of Human Organs Act, 1994 (THOA), the donor’s suitability will be determined by the transplant surgeon. The donor must be older than 18 years old.

Q. What transpires to the donor’s liver following surgery?

Since the liver is the only organ in the body that has the ability to regenerate, the donor liver will return to normal after 8–12 weeks.

Q. How much time will the patient and donor need to spend in the hospital?

The patient needs to stay in the hospital for about three weeks (which may vary as per the condition and other factors) in order to fully recover, whereas the donor is discharged after just one week.

Q. What is the survival rate for kids who have had liver transplants?

Numerous variables, including the child’s age and health status, affect the survival rate. Our outcomes, however, are on par with those of the most reputable facilities worldwide.

A paediatric liver transplant is a surgical procedure carried out in India to remove a diseased liver and replace it with a healthy one. It is very effective in treating children with liver diseases that cannot be treated with standard drugs and surgeries and gives them the chance to live a long and healthy life.

Dr. Surbhi Suden

Verified By Dr. Surbhi Suden

Dr. Surbhi Suden is one of the founders of Lyfboat and a doctor with a renowned name in the Medical tourism industry. She has been working with international patients since 2008 and is a deeply committed professional with a long term vision of transforming the current healthcare scenarios.

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Dr. Surbhi Suden is one of the founders of Lyfboat and a doctor with a renowned name in the Medical tourism industry. She has been working with international patients since 2008 and is a deeply committed professional with a long term vision of transforming the current healthcare scenarios.
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