Stem Cell Therapy for Cerebral Palsy in Turkey

“The cost of Stem Cell Therapy for Cerebral Palsy in Turkey starts from EUR 6,000. Cost includes examination, Stem Cell Therapy, TMS and Ozone sessions (10 sessions each) and 1 Reminder dose.

About Cerebral Palsy

The term “cerebral palsy” (CP) refers to a non-progressive brain condition that makes it difficult for a person to move because their muscles are too stiff or lack coordination.

Over time, Cerebral Palsy does not get worse (non-progressive). However, as the youngster gets older, the limb or component connected to that injured part may gradually lose its function. These areas might not develop as much as the rest of the body.

A cerebral palsy patient may exhibit intellectual or motor function problems, depending on the severity of the brain injury. Thus, the term “cerebral palsy” is frequently used to refer to a group of brain-related diseases when there is an impairment in voluntary movement or coordination.

It grows during the perinatal period and occurs more frequently in preterm infants. It is due to nerve system lesions and is chronic in character rather than progressive.

Symptoms of Cerebral Palsy

Along with epilepsy and concomitant mental impairment, the illness also causes physical disabilities that range in severity from minor to extremely severe.
Usually, cerebral palsy symptoms do not become visible right away after a baby is delivered. They often become apparent throughout a child’s first two or three years of life.
The disease has various manifestations. This is because the diseased process in each unique case involves different cerebral cortex regions and subcortical systems.

Movement and development problems

The main symptoms of cerebral palsy are problems with movement, coordination, and development. Although the intensity of the symptoms varies greatly from child to child, possible signs in a child include:

delays in reaching development milestones – for example, not sitting by 8 months or not walking by 18 months
seeming too stiff or too floppy (hypotonia)
weak arms or legs
fidgety, jerky, or clumsy movements
random, uncontrolled movements
muscle spasms
shaking hands (tremors)
walking on tiptoes

Difficulty in

Walking
Eating
Speech intellectual ability
Eye coordination
Motor and balance control
Muscle movement

People with cerebral palsy can also have a range of other problems, including:

feeding, drooling and swallowing difficulties
constipation
problems with speaking and communication
seizures or fits (epilepsy)
difficulty falling asleep and/or staying asleep
gastro-oesophageal reflux disease (GORD) – where acid from the stomach leaks up into the oesophagus (gullet)
an abnormally curved spine (scoliosis)
hips that pop out (dislocate) easily
difficulty controlling the bladder (urinary incontinence)
a learning disability – about half of the children with cerebral palsy have a learning disability
eye problems – including reduced vision, a squint, or uncontrollable eye movements
hearing loss

The bodily components that are impacted might also differ. It might happen that only one side of the body is afflicted, that the entire body is impacted, or that the legs are the major area of concern.

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Types of Cerebral Palsy

The damaged brain region determines the sort of cerebral palsy a kid will have.

The diagnosis of the condition is made via an MRI brain scan.

Before the conclusion is reached, more observations are made. These observations could include crawling, sitting posture, and walking. There are four distinct forms of cerebral palsy, including:

Spastic Cerebral Palsy: Movement is challenging and the range of motion is limited due to the muscles’ stiffness and tightness (particularly when moving them fast).

Dyskinetic Cerebral Palsy: causes erratic, out-of-control bodily motions or spasms because the muscles alternate between being rigid and floppy.

Ataxic Cerebral Palsy: when a person has balance coordination problems, resulting in shaky or clumsy movements and sometimes tremors
Mixed Cerebral Palsy: when a person has symptoms of more than one type of cerebral palsy

Terms such as hemiplegia or diplegia, monoplegia, and quadriplegia refer to the parts of the body affected by cerebral palsy.

Hemiplegia means one side of the body is affected
Diplegia is where 2 limbs are affected
Monoplegia is where one limb is affected
Quadriplegia is where all 4 limbs (and usually the whole body) are affected.

Diagnosis

Imaging examinations are used to identify any brain damage and make a diagnosis of cerebral palsy.

Imaging tests used to diagnose cerebral palsy include:
Computed tomography (CT) scans
Cranial ultrasounds
Electroencephalograms (EEG)
Magnetic resonance imaging (MRI) scans

After a diagnosis is determined, parents may start treating their child’s condition and controlling it.

Cerebral Palsy Prognosis

Factors affecting a cerebral palsy prognosis include:

Difficulties with eating and swallowing
Impairments in vision, hearing, or speech
Intellectual disabilities
Mobility limitations
Musculoskeletal disorders
Respiratory disorders
Seizures

Depending on how the illness is treated, physical symptoms and motor abilities may get better or worse over time. Physical and neurological symptoms should be properly treated to alleviate any pain and enhance prognosis.

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Treatment of Cerebral Palsy

Cerebral palsy treatment is not focused on curing or fully correcting a child’s condition. Once a child has developed cerebral palsy, it cannot be cured. Instead, treatment focuses on nurturing a child’s remaining skills to reduce symptoms and encourage an independent life.
The greatest method to guarantee that a child with cerebral palsy has the maximum quality of life as they grow into adults is to actively address their symptoms. The doctor will develop a treatment strategy that takes into account the child’s unique requirements.
To support brain development, infants with cerebral palsy may need early medical care. Around this stage, there are more chances to enhance or repair some of the child’s movement issues.

Types of treatment used to treat cerebral palsy in leading Turkish clinics:

Hospitals are staffed by teams of doctors specializing in the treatment of this ailment.
Physiotherapy.
Drug therapy.
Orthopaedic aid.
Rehabilitation.
Training in movements, and development of fine motor skills.
Speech enhancement
Neurosurgical operations according to indications.

Therapy as Treatment

The symptoms of cerebral palsy can be treated with a variety of therapies. Therapy can help with mobility and cognitive function.

Physical therapy: Aids in reducing pain and muscular stiffness and enhances mobility by enhancing balance and coordination. Physical therapists will make use of specialist tools to enable individuals to move around more easily and lead more autonomous life.

Occupational therapy: By enhancing fine motor skills and cognitive abilities, people with cerebral palsy can learn how to execute common chores and activities.

Speech therapy: Assists in developing language and communication abilities.

Alternative therapy helps individuals get through physical and emotional challenges. Hippotherapy (which involves horseback riding), music therapy, water therapy, acupuncture, and other forms of alternative treatment are among them.

Surgery as Treatment

Surgery for cerebral palsy can fix or enhance mobility problems in the hips, wrists, ankles, and legs. To increase mobility in various bodily parts, operations are performed on muscles, tendons, bones, and nerves.

Cerebral palsy surgery can:

Correct fixed joints and tendons
Correct foot deformities
Correct muscle contractures
Correct spinal curvatures (scoliosis)
Improve balance and coordination
Improve posture
Prevent hip dislocation
Prevent spinal deformities
Reduce tremors
Relieve pain
Relieve stiff muscles
Treat co-occurring conditions

Assistive Devices for Treatment

Specialized assistive devices can help individuals with cerebral palsy that experienced issues with communication, hearing, and vision.

Types of assistive devices include:

Cochlear implants
Electronic communication boards
Eye-tracking devices
Typing aids
Writing aids

Significance of Stem Cells as a Therapy for Cerebral Palsy

Regenerative medicine, a cutting-edge branch of medicine that deals with the process of healing or regenerating the body’s damaged tissues, includes stem cell treatment as a type of cellular therapy.

Stem cells are undifferentiated, undeveloped cells that can develop into any other type of cell with specialized tasks. Their ability to self-renew and differentiate into different types of cells, such as muscle, heart, and brain cells, among others, are their two distinguishing characteristics.

Using these special characteristics of stem cells, stem cell therapy can treat some medical diseases or stop them from getting worse. Primarily, there are three categories of stem cells that can be applied:

Embryonic stem cells (ESCs)
Adult stem cells
Umbilical cord stem cells

For stem cell therapy, cells may be obtained from two sources:

Autologous

Stem cells are taken from the patient’s own body for transplantation. The benefits of this method are – the risk of rejection is neutralized as self-cells are used and the chances of side effects are minimized.

Allogeneic

The stem cells are obtained from another person (donor) and transplanted into the patient. The donor needs to be tested for genetic compatibility before extracting the cells for transplant. Umbilical cord stem cells can also be used for this type of transplant.

Effects of Stem Cell Treatment on Patients with Cerebral Palsy

The currently available treatment options for cerebral palsy can help patients in managing symptoms to a limited level. They cannot repair the actual brain damage.

Stem cell therapy is a promising regenerative medicine technique that can be a potential treatment option for patients with cerebral palsy.

The mechanisms by which stem may help in tissue repair and regeneration include: –

Replace the damaged neural cells
Release growth factors to promote recovery
Prevent cell death of neurons
Establish new blood vessels
Regenerate neural cells by stimulating cell multiplication and integration
Help in establishing new neural maps in the brain to promote learning new functions.

These mechanisms can ultimately help in restoring activity in the affected area, which results in improvements in clinical symptoms and improving the overall quality of life of the patients.

Procedure of Cerebral Palsy Stem Cell Therapy in Turkey

The hip region will first be cleaned and anesthetized by the doctor.
The iliac crest, a portion of the pelvic bone, is then punctured with a needle. After using a specialized syringe to remove the bone marrow, the sample is sent to a lab.
The doctor will next clean and numb the patient’s affected region in preparation for treatment.
Under the guidance of advanced X-rays, the doctor administers the stem cells to the injured location. The patient may often go home the same day after finishing the procedure, which typically takes less than an hour.

Cerebral Palsy Stem Cell Therapy Recovery Time in Turkey

During 3-6 months of cell therapy, most of the advantages become apparent. Some people’s recovery times might range from months to even years. But even before they are sent home, the majority of patients show some early signs of recovery.

After Cerebral Palsy Stem Cell Therapy

The stem cell procedure will take three to four hours to complete. They can typically return to work and carry out daily tasks within two days. After surgery, they should take it easy and refrain from any load-bearing activities for at least three weeks. During the course of six to twelve months, many patients may continue to improve, experiencing less inflammation, reduced pain, and more mobility and function.

Cerebral Palsy Stem Cell Therapy Advantages in Turkey

Stem cell therapy is painless since it does not require surgery.
The procedure does not require the patient to stay in the hospital for an extended period of time, and he or she is discharged after a few days.
The procedure is simple and takes only a short amount of time. The entire operation consists of obtaining bone marrow and then injecting it once it has been filtered.
The stem cells speed up the body’s natural healing process and reduce pain without the need for painkillers.
Even when the cells are dormant, they proliferate swiftly and divide into new areas.

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