Fanconi’s Anemia is caused by a rare genetic abnormality that leads to the DNAs inability to repair itself. As a result of the abnormality, the DNA breaks or rearranges itself easily a condition known as chromosome instability. Fanconi’s Anemia is an inherited disease, which means that the disease is passed to the children through faulty genes from the parents.
There have been eighteen gene abnormalities linked to occurrences of FA. If only one parent has one of the faulty genes and passes it on to the child, the child will be a carrier of the gene but will not develop the disease. When both parents have the same faulty gene, and both pass it on to the child, then the child will develop Fanconi’s Anemia.
If only one parent passes on the faulty gene then the child will be a carrier, and can pass the gene or the disease, on to their own children but they do not, themselves, develop the disease. When both parents possess the faulty gene there is a 25% chance of having Fanconi’s Anemia and a 50% chance of being a carrier. If only one of the parents has a faulty gene, the child won’t have the disorder but will have a 50% chance of being an FA carrier and passing the gene to their children.