Bone Marrow Transplant Cost in India

What is Cost of Bone Marrow Transplant in India?

“The Cost of Autologous stem cell transplant starts from US$ 15,000 in India”
“The Cost Allogeneic bone marrow transplant starts from US$ 25,000 in India.”

Bone marrow transplant cost in India starts at as low as $15,000, but this rate varies with several factors such as:

  • Availability of Donor.
  • Type of transplant required
  • Choice of Hospital : The cost of bone marrow transplant also differs based on the choice of the hospital. Every hospital has its own examination and test facilities, infrastructure, support and surgeon fees that eventually add to the total transplant cost.
  • Duration of hospital stay
  • Specialist’s fees

For every transplant case, an allocated case manager is appointed who takes a personalized interest in designing the treatment plan for every patient and the bone marrow transplant cost package. The cost of bone marrow transplant also differs based on the type of the hospital. Every hospital has its own examination and test facilities, infrastructure, support and surgeon fees that eventually add to the total transplant cost.

Bone marrow biospy

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What are the types of Bone Marrow Transplant?

The following are the two types of bone marrow transplant:

Autologous Transplant:

In this type, the hematopoietic cells procured from the body of the patient is kept in a deep freezer before high-dose chemotherapy and radiation therapy is initiated for cancer treatment. Once the therapies are administered, the cancer cells are destroyed and in the process, normal cells are badly affected. After the therapies are over, the stored hematopoietic cells that were kept in the freezer are transplanted again into the patient’s body.

infographics-allogeneic

Allogenic Transplant:

This type of bone marrow transplant involves extracting the donor’s bone marrow, also called peripheral stem cells. This bone marrow is matched genetically and may or may not relate to you. Doctors may follow syngeneic bone marrow transplant that includes receiving peripheral stem cells and bone marrow of identical twins.

Who can donate bone marrow?

When a patient suffers from diseased or damaged bone marrow that is unable to produce good and healthy blood cells, he or she needs the stem cells derived from a donor for transplant. A person is eligible to become a BMT donor if his or her tissues closely match with that of the patient’s tissues.

Generally, a matching donor is from the immediate family, a child, a sister or brother or a parent. However, if a person is lucky then he or she can get the best match in a volunteer too. A cent percent match is not necessary, but the close match with a positive outcome is indispensable.

Another source of BMT cells is from the placenta and umbilical cord of a newborn. If these cells are collected from the baby and then frozen in a stem cell bank, they can be successfully used later for bone marrow transplant. This type of transplant is clinically termed cord blood transplant.

What happens during bone marrow transplant?

Bone marrow is a soft tissue present inside the bones that produce WBCs, RBCs and platelets. If the stem cells fail to produce normal and healthy blood cells, then doctors recommend bone marrow transplant for replacing diseased bone marrow with a healthy one. This new stem cell is taken from a donor and implanted in the recipient’s body that further helps to produce healthy blood cells.

Sometimes for the treatment of certain cancers, the bone marrow is taken from the body of the patient itself before transplanting it back into their bodies. In the middle of the two procedures, the patient is made to undergo radiation treatment and chemotherapy, which end up destroying the healthy bone marrow. The bone marrows retrieved from the body of the patient before radiation and chemo is then transplanted.

What are the precaution to be taken before and after bone marrow transplant?

The precautions to be taken before and after bone marrow transplant should be followed comprehensively. Prior to getting approval for bone marrow transplant, the patient has to undergo pre-transplant evaluation.

The evaluation procedure involves consultation and discussion with members of the BMT team. Then, a series of tests is performed to assess if the patient is eligible for getting a transplant. Once you have been approved as a good candidate for bone marrow transplant, a BMT date is fixed and insurance clearance process begins.

Post bone marrow transplant, the patient suffers from a very low immune system for two to four weeks, which makes him or her susceptible to infections. Hence, the patient is put under observation and is persistently and religiously administered medications and antibiotics. The idea is to protect the patient from fungal and viral infections.

After the first one month, the graft implanted settles and produces blood cells in the bone marrow, thus improving the host’s condition. Once the graft takes hold of the recipient, drugs that were given to suppress immunity are withdrawn. Sometimes, many patients require re-immunization, which is possible through vaccines.

How can Lyfboat assist you getting Bone Marrow Transplant Surgery in India?

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Lyfboat makes it easy for you to get quality medical opinions and find the right healthcare providers in India for bone marrow transplant surgery at best prices. It is a free to use platform; we do not charge any fees from patients. In fact, we negotiate the price that hospitals offer. In some cases, we are able to reduce the cost by up to 20% of what Hospitals generally offer.

Why people prefer bone marrow transplant in India?

Today, India has three most popular bone marrow registries, based in Chennai, and another in Delhi. The available procedures for bone marrow transplant in India include autologous transplant and allogeneic transplant.

In 2005, an extensive study was conducted from six different and most renowned transplant centers in India. The study revealed that an approximate 1,540 transplants were conducted successfully in India having a population of over a billion. India has a vision of ensuring affordable bone marrow transplant cost for the countrymen and foreign nationals traveling here to seek treatment as well. Today, the Bangalore City takes an immense pride in having the largest bone marrow transplant facility in the country.

How much time does it take to recover after Bone Marrow Transplant?

Autologous bone marrow transplant recovery time is usually one month, while allogeneic bone marrow transplant recovery time is at least three months. Blood count usually starts to improve only after 10 to 20 days after the transplant. In the process, the patient is continuously monitored so as to keep infections at bay. When the blood count rises, the patient’s medical condition shows better signs of improvement.

What are the complications of Bone Marrow Transplant?

Some of the complications of bone marrow transplant include bleeding, infection, liver disease and graft-versus-host disease. The pain from the complications arising out of the transplant is controlled by medication. In addition to these, mouth sores may develop making swallowing and chewing uncomfortable. Sometimes, temporary mental confusion is another major sign of complications after bone marrow transplant.

Bone Marrow Transplant Risks 

  • Infections: Post transplant the first 2-3 weeks are very crucial as the new bone marrow grows and produces white blood cells. A good antibiotic coverage helps the patients against infections 
  • Mucositis or Mouth sores: It is an inflammation of the lining of the mouth or gastrointestinal (GI) tract and the most common side effect of stem cell therapy.
  • Veno-Occlusive Disease of the Liver (VOD): High-dose chemotherapy can result in damage to the liver and this usually occurs in the first 2 weeks after high-dose chemotherapy treatment 
  • Interstitial Pneumonia Syndrome (IPS): IPS can occur anytime soon after the transplant and damage the cells of the lungs. Most commonly it is seen in patients who have had exposure to certain types of chemotherapy and/or radiation therapy given prior to the transplant. 
  • Graft-versus-Host Disease: It is a condition that develops when a donor transplant’s immune cells attack the recipient’s tissues.
  • Graft Failure: The graft fails to grow or is rejected in the patient, resulting in bone marrow failure 
  • Cataracts: Cataracts are a common long-term side effect too and it typically begins 18-24 months following the chemotherapy
  • Infertility: Sterility is another common side effect of chemotherapy but in few cases some prepubertal and adolescent females do recover ovulation and regular menstrual cycles.
  • New cancers: Along with relapse “secondary cancers” may occur as a late complication of high-dose chemotherapy.

Top Bone Marrow Transplant Hospitals in India

India hosts over 200 top-notch bone marrow transplant hospitals across the major cities such as New Delhi, Ahmedabad, Chennai, Bangalore, Gurgaon and Goa. These hospitals have the best trained and experienced doctors, surgeons and nurses who are dedicated to providing personalised care and specialised services to bone marrow transplant patients.

The donor is required to stay a night at the hospitals to complete bone marrow transplant procedure. Once the stems are collected, they are sent to the laboratory for harvesting. Then, blood transfusion is performed on the body of the recipient with the help of an injection.

Remember, every cancer hospital and super-speciality unit evaluates the health condition of the patient and whether he or she is capable of tolerating certain medications before the transplant procedure and after it. If everything is fine, the patient is given a go ahead to undergo the transplant procedure.

Best Bone Marrow Transplant Specialists in India

The country boasts of stringent infection control regulations, experienced surgeons, multi-facilitated hospitals and advanced treatment facilities.

List of some famous bone marrow transplant specialists:

Frequently Asked Questions (FAQs) about Bone Marrow Transplant in India

Q. What is bone marrow and why is it required?

Bone marrow is a spongy tissue, which is present inside the breastbone or bones in the skull, ribs, spine and hips. This spongy tissue comprises of stem cells that help produce three types of blood cells in the human body. These include red blood cells, white blood cells, and platelets.

Red blood cells, also known as erythrocytes, help to carry oxygen in the blood and eliminate waste from it, while white blood cells, known as leukocytes, help to fight infection. Platelets, on the other hand, enable blood to clot.

Q. Why is Bone Marrow Transplant performed?

Bone marrow transplant helps provide a new lease of life to patients suffering from life-threatening conditions, including leukemia or multiple myeloma.

Q. How do they do a bone marrow transplant?

Bone marrow is a soft tissue present inside the bones that produce WBCs, RBCs, and platelets. If the stem cells fail to produce normal and healthy blood cells, then doctors recommend bone marrow transplant for replacing diseased bone marrow with a healthy one. This new stem cell is taken from a donor and implanted in the recipient’s body that further helps to produce healthy blood cells.

Sometimes for the treatment of certain cancers, the bone marrow is taken from the body of the patient itself before transplanting it back into their bodies. In the middle of the two procedures, the patient is made to undergo radiation treatment and chemotherapy, which end up destroying the healthy bone marrow. The bone marrows retrieved from the body of the patient before radiation and chemo is then transplanted.

Q. Can I undergo bone marrow transplant?

The best candidates for bone marrow transplant include individuals who are suffering from diseases certain forms of blood cancer such as myelodysplasia, leukemia, lymphoma and multiple myeloma, thalassemia, severe immunodeficiency syndrome, aplastic anemia, low blood cells counts, immature blood cells, excessive production of immature blood cells, sickle cell anemia and congenital neutropenia.

The cancer patients may require stem cell transplant if their bone marrow gets damaged by radiation or chemotherapy. The only treatment for this medical condition is radiation or chemotherapy. The chemotherapy and radiation treatment procedure help to destroy abnormal blood cells and abnormal stem cells.

However, in the process, the normal cells are also destroyed. At the same time, aggressive chemotherapy can even damage healthy bone marrow. Only a bone marrow transplant can help save the patient by replacing the destroyed bone marrow.

Q. How do you donate bone marrow?

When a patient suffers from diseased or damaged bone marrow that is unable to produce good and healthy blood cells, he or she needs the stem cells derived from a donor for transplant. A person is eligible to become a BMT donor if his or her tissues closely match with that of the patient’s tissues.

Generally, a matching donor is from the immediate family, a child, a sister or brother or a parent. However, if a person is lucky then he or she can get the best match in a volunteer too. A cent percent match is not necessary, but the close match with a positive outcome is indispensable.

Another source of BMT cells is from the placenta and umbilical cord of a newborn. If these cells are collected from the baby and then frozen in a stem cell bank, they can be successfully used later for bone marrow transplant. This type of transplant is clinically termed cord blood transplant.

Q. Is it painful to be a bone marrow donor?

The notion that bone marrow donation is painful is a myth. A large majority of people who have donated some bit of their bone marrow confess themselves that it is a completely painless and comfortable procedure.

Bone marrows can be derived by two methods – either from the pelvic bone under the influence of general anaesthesia or from the blood stream of the patient. Prior to the second procedure, the donor is given hormone injections to make the stem cells multiply in the blood stream itself. Next, blood is taken from the donor to extract stem cells from them.

Q. Is it dangerous to donate bone marrow?

Bone marrow donation is a simple, outpatient, and painless procedure. The donor can go home on the same day of donation but may feel a bit tired for a few days. Otherwise, it is a completely safe and risk-less procedure. The only major risk that the donor suffers from is a reaction to anaesthesia, but it is a very rare complication. Donors aged between 18 and 44 are considered to be the best candidates for bone marrow donation because of minimal risk of complications.

Q. What to expect after bone marrow transplant?

Life can be both worrisome and exhilarating post bone marrow transplant. Patients have to visit doctors often to be closely monitored. However, a bone marrow transplant is, indeed, a blessing after being close to death. Life can drastically improve after the transplant.

Q. What are stem cells?

Stem cells have the potential to develop into some or many different types of cell in the body. It depends on whether they are pluripotent or multipotent. They Serves as a sort of repair system. They can theoretically divide without limit to replenish other cells for as long as the patient is alive. Each daughter cell has the potential to either remain a stem cell or become another type of cell with a more specialized function in case od division of cells. Some of the examples of these cells are muscle cell, red blood cell, or brain cell.

Q. What are the classes of stem cells?

There are two classes of stem cells. These may be pluripotent or multipotent.

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