Cost of Acute Lymphocytic Leukemia Treatment in India

Last Modified: October 6, 2021  |   Created on: September 20, 2021
Blood Cancer, Transplants

Highlights

  • Acute lymphocytic leukemia affects the T and B lymphocytes.
  • ALL is more common in males and prevalent among children of 2-5 years of age.
  • ALL starts in the bone marrow and spreads to the blood, central nervous system, lymph nodes, spleen, liver, and testicles.
  • ALL can be treated by chemotherapy, target drug therapy, and radiation therapy. 
  • The cost of Bone Marrow Transplant for ALL treatment in India starts from 15,000 USD.
ALL Treatment cost in India
  • Acute lymphocytic leukemia is a result of immature abnormal blasts cells turning cancerous. The blast cells proliferate and divide; however, they do not mature to form functional lymphocytes.
  • ALL is the most common type of leukemia affecting children
  • It is also known as acute lymphoblastic leukemia.

The signs and symptoms of ALL cancer may include:

  • Gum or nose bleeding
  • Fever and pain in bones
  • Recurrent infections
  • Lumps around the neck, armpits, abdomen, and groin
  • Pale skin
  • Difficulty in breathing
  • Fatigue and decreased energy levels

Cause of Acute Lymphocytic leukemia

DNA present inside the cell regulates its growth and proper functioning. It has multiple genes that stimulate or inhibit cell proliferation and differentiation.

Sudden changes in the DNA, called mutations, impair the cell machinery. It leads to the formation of immature and abnormal blasts in the bone marrow.

The exact cause of DNA mutation is not specified, but many risk factors are associated with Acute lymphocytic leukemia. 

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Detection of Acute lymphocytic leukemia

Detection of Acute lymphocytic leukemia begins with a thorough medical examination by the doctor. After evaluating all the patient’s signs, symptoms, and medical history, the doctor will plan a treatment plan accordingly. 

Condition

Percentage of Blasts in Bone marrow

Normal bone marrow

<5%

Acute Lymphocytic leukemia

>20%

Various tests involved in the diagnosis of ALL are:

Complete blood count (CBC): This test identifies the count of different cells in the patient’s blood sample. 

Peripheral blood smear: This test helps to detect abnormalities in the shape and size of different blood cells. 

Blood chemistry/coagulation tests: This test detects possible liver damage and examines the blood clotting factors. 

Cytochemistry test: This test helps a pathologist to distinguish leukemic cells resembling black spots under the microscope. The cells are mixed with a cell-specific dye. The dye is only taken up by abnormal leukemic cells. 

Flowcytometry: This method of cell detection uses a specialized machine called a flow cytometer. The cells sample is treated with antigen-specific antibodies that target leukemic cells. Then, the antibody-bound cells are counted with the help of the flow cytometer. 

Chromosome test: Cytogenetics, FISH, and Polymerase chain reaction (PCR) are used to identify malformations and mutations in the cell’s genetic material.

Lumbar puncture: This test helps a doctor to analyze whether ALL has spread across the cerebrospinal fluid or not. 

Imaging tests: Imaging tests like X-rays, CT scans, MRI scans, and Ultrasound are done to evaluate the structure and function of different body parts that may be affected due to ALL. 

What is the cost of Acute lymphocytic leukemia treatment in India?

Treatment

Induction Chemotherapy

Consolidatory Chemotherapy

Maintenance Chemotherapy

Bone Marrow Transplant

Cost

12,000 USD

3500-4000 USD/month

3500-4000 USD/month

Autologous transplant: 15,000 USD

Allogenic transplant (Full-match): 22,000 USD

Allogenic transplant (Half match): 40,000 USD

Duration

2 weeks

3-4 months

18 months to 2 years

7-10 days

Type

Inpatient

Outpatient

Outpatient

Inpatient / Outpatient

 

Factors that affect the cost of ALL treatment are:

  1. Type of room and location of the hospital
  2. Type of treatment suggested by the doctor 
  3. Experience of the doctor
  4. Cost of additional medicines or procedures
  5. Follow-up care and treatment

How can Lyfboat assist you getting Acute lymphocytic treatment in India?

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Lyfboat is a free advisory platform; we do not charge any fees from patients. In fact, we negotiate the price that Indian hospitals offer. In some cases we are able to reduce the cost by negotiating upto 20% of what Hospitals generally offer. We advise the best treatment from the top hospital/surgeon at best price.

What happens after you reach India for undergoing Acute lymphocytic leukemia treatment?

Evaluation

The treatment of acute lymphocytic leukemia begins with a consultation with a specialist. The doctor will assess all the signs, symptoms, and medical history of the patient. 

Duration: 1 or 2 days

First Bone marrow biopsy and blood tests

The doctor suggests a bone marrow biopsy to determine the percentage of blasts in the bone marrow. The procedure is as follows:

  1. The doctor will numb the area around the hip bone by injecting local anesthesia. 
  2. Then, a needle will be injected to collect a sample of bone marrow. Finally, the collected sample is processed in the laboratory, and a pathologist examines it for any possible abnormalities. 
  3. Blood tests like CBC, Blood chemistry test, coagulation test, etc., will also be conducted. 

Duration: 5 to 7 days

Induction chemotherapy

Induction marks the first stage of the treatment. It is an intensive procedure that targets immature blasts present in the body to bring them down to a normal range. It is followed by Preventive treatment of the spinal cord that includes injection of chemotherapy drugs into the CSF fluid. This step is necessary to prevent the spread of ALL in the central nervous system. 

Type of procedure: In-patient

Duration: 2 weeks

Second Bone marrow Biopsy 

Following induction chemotherapy, a second bone marrow biopsy is conducted. The results of this test help the doctor to choose between bone marrow transplant or Consolidatory chemotherapy. 

  1. High-risk AML: No significant change in the overall blast percentage. 
  2. Low-risk AML: Considerable drop in the percentage of blasts. 

Duration: 5 to 7 days

Consolidatory chemotherapy

Conduction is the second stage or phase of ALL treatment. It kills the residual percentage of blasts in the bone marrow after remission. Consolidatory chemotherapy is given in cycles and includes a period of rest after each treatment. It also follows the Preventive treatment of the spinal cord. 

Type of procedure: Out-patient

Duration: 3 to 4 months

Bone marrow transplant

A bone marrow transplant involves the transfer of cells from the donor to the recipient. It can be autologous or allogenic, depending on the source of bone marrow cells. The steps involved in the procedure are:

  1. The doctor numbs the area around the hip region and injects a syringe into the pelvic bone.
  2. The bone marrow is aspirated through the needle, and the sample is sent to the laboratory.
  3. The processed sample is infused back into the patient’s body after a round of chemotherapy.  

Type of procedure: Can be in-patient or out-patient

Duration: 7 to 10 days

Maintenance chemotherapy

This therapy is only advised if the patient will not need a bone marrow transplant. It aims to increase the remission period to prevent recurrence or relapse of ALL in patients. It can be given in the form of oral tablets or administered intravenously. 

Type of procedure: Out-patient

Duration: 1.5 to 2 years

Post-treatment care

The doctor may prescribe specific medication or therapies as a part of post-treatment care and recovery. Routine tests like CBC, Peripheral blood smear, etc., help to establish the next phase of the treatment, if necessary. 

Frequently asked Questions (FAQs) about ALL Treatment in India

Q. What are the risk factors associated with Acute lymphocytic leukemia?

The various risk factors associated with acute lymphocytic leukemia are:

  • Children from 2-5 years of age and adults above 50 years of age
  • Exposure to chemicals or radiation
  • Viral infections like human T-cell lymphoma/leukemia virus-1 (HTLV-1), Epstein-Barr virus (EBV), etc.
  • Treatment with chemotherapy drugs
  • Genetic syndrome
  • Family history of AML
  • Identical twin with ALL
  • Exposure to electromagnetic fields

Q. What body parts are affected by Acute lymphocytic leukemia?

ALL can spread to and infect the blood, central nervous system, lymph nodes, spleen, liver, and testicles.

Q. Who treats Acute lymphocytic leukemia?

Acute lymphocytic leukemia is treated by:

Hematologist: A specialist treating disorders of the blood

Medical Oncologist: A specialist treating cancer with medicines

Q. Are there any side effects of the treatment?

The most common side effects of treatment involved in ALL are:

  • Compromised immunity
  • Anemia and fatigue
  • Mouth sores
  • Change of taste
  • Alteration in cardiac muscles
  • Hair loss
  • Irregular or no menstruation in females
  • Reduced sperm production

Q. What is the success rate of Acute lymphocytic leukemia treatment?

The success of ALL treatment depends on various factors, including age, lifestyle, and the patient’s body’s response towards the therapies. There is more chance of success in ALL cases where remission is achieved after 4-5 weeks.

Patients below the age of 50 are also reported to have a faster recovery. Lastly, ALL affecting the T cells have more successful recovery chances than ALL targeting mature B cells. 

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Simran Bahia

Written By Simran Bahia

Simran Bahia is an experienced content writer with extensive research experience in Immunology and Reproductive Biology. Simran received her Bachelors in Life Sciences from Delhi University, followed by a Master's in Immunology from the Amity Institute of Virology and Immunology. Combining her love for science and writing, Simran enjoys putting a spin on standard methods of medical writing.

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