IVF in Turkey

Last Modified: October 16, 2020  |   Created on: August 28, 2020
Gynecology

Infertility has become a common concern for people everywhere and it can affect women as well as men. In vitro fertilization or IVF is the most popular reproductive medicine technique that aims to help couples who are unable to conceive naturally despite several attempts. 

It involves a combination of medicine based treatments and invasive procedures that may result in a successfully pregnant. As there has been many advancements in the filed of fertility treatment, IVF is also being used for genetic screening and aid in preventing some kinds of congenital defects. 

Although, IVF is a safe procedure and has gained immense popularity, its success depends on many medical and individual related factors. Some patients may require multiple IVF cycles before they can successfully conceive. It can also be combined with other assisted reproductive techniques such as ICSI, genetic screening, donor eggs and others.

Turkey-IVF

IVF Cost in Turkey

Turkey is a major hub for advanced healthcare procedures and treatments. As it has parts in two continents – the Europe and Asia, is near proximity with the Middle East, people from various countries travel to this country for quality medical care. IVF in Turkey is a safe procedure that is performed in accredited and internationally certified clinics/hospitals. 

There are many reasons to choose IVF treatment in Turkey

  • World-class hospitals: The IVF clinics in Turkey are specialized centres dedicated to fertility treatment for men and women. There are many hospitals in major cities that offer holistic and personalized care to couples who want to conceive through this method. The best IVF hospital in Turkey are equipped with the latest medical equipment and technology for gynaecology and obstetrics procedures. They have advanced fertility centres, labour rooms/suites, Neonatal ICUs and other services. Medicana IVF centre in Turkey is one of the most renowned facilities that cater to domestic and international patients. 
  • Experienced doctors: The gynaecologists and IVF specialists in the country are highly qualified and skilled experts. They have years of experience in the field and are proficient in various kinds of advanced reproductive medicine techniques. They are trained and up-to-date with the latest developments in this field. 
  • Low prices: IVF treatment cost in Turkey is relatively lower compared to the price for the same procedures in other countries such as the USA, UK, Germany and many more. The packages offered by Medicana International Istanbul hospital IVF is appreciated by patients from all parts of the world for its high quality and reasonable price. 
  • High IVF success rates in Turkey: With advanced medical technology and experienced doctors, the success and patient satisfaction rate for IVF Turkey is as good as, if not more, the top facilities of the world. 

To know more about the best IVF clinic in Turkey, share your medical reports with us on care@lyfboat.com. Our team will assist you throughout the process and help locate the most suitable centres for their treatment.

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Factors that affect the IVF cost in Turkey

The overall IVF Turkey prices vary depending on several patient based and other factors, including

  • The accreditations, location and quality of services at the hospital
  • Doctor’s experience
  • Length of stay in the country
  • Choice of accommodation
  • Whether other treatments for infertility are required (depending on the reason for infertility)
  • Whether additional procedures are required

The Turkey IVF packages is inclusive of pre-evaluation tests, procedure, and other related services. However, it may vary for different hospitals and other tests or procedures might be recommended after initial consultation with the doctor. The medical team will conduct several tests to assess the patient’s infertility condition and overall health to determine the case-specific risks for developing post-operative complications.

In Vitro Fertilization

In vitro fertilization is a series of complex procedure involving fertilization of eggs and sperms in a laboratory, and followed by embryo implantation which may lead to pregnancy. The eggs produced by the ovaries are collected through a minor procedure using special needles and these eggs are combined with sperms collected from the male partner in a petri dish for fertilization. 

The embryo(s) is/are transferred into the uterus of the women where it may get successfully implanted and grow during the pregnancy. The baby conceived through IVF was popular known as ‘test tube baby’. More than one egg is usually harvested for this method and it is under anesthesia, using an ultrasound guidance system.

The success rate of the IVF treatment depends on some fertility and health-related characteristics of the couple. The IVF success rate is generally influenced by factors such as ovarian reserve, age, serious male sperm factor, and overall health of the women. Couples can opt for donor eggs or sperms in the IVF method. 

Surrogacy is also an option for women who can’t sustain the pregnancy themselves due to health factors or other reasons. Also, artificial insemination methods or intra cytoplasmic sperm injection (ICSI) methods can be opted to increase the chances of fertilization. For women who undergo IVF, the success rate is around 55-60% if they are less than 35 years old and have good ovarian reserve, whereas the success rate for women older than 40 is around 30%. 

As there is higher risk of developing genetic anomaly if the women is in this age group, pre-implantation genetic diagnosis is considered. The experts can help select the genetically normal embryo, which is then transferred to increase the chance of conception.

How can Lyfboat assist you getting IVF Treatment in Turkey?

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Lyfboat is a free advisory platform; we do not charge any fees from patients. In fact, we negotiate the price that Indian hospitals offer. In some cases we are able to reduce the cost by negotiating upto 20% of what Hospitals generally offer. We advise the best treatment from the top hospital/surgeon at best price.

Who can be a good candidate of the IVF treatment?

Women with following conditions may consider IVF to conceive:

  • surgically removed Fallopian Tubes
  • reduced fertility over the age of 40
  • Endometriosis or those who cannot conceive with the help of surgical treatment
  • Ovary related problems that do not respond to medical treatment
  • Diagnosed with idiopathic or unexplained infertility
  • Antibody reaction that harm sperm or eggs
  • Inability of sperm to penetrate through or survive in the cervical mucus
  • Poor egg quality or reserve 
  • Genetic disease 

Male infertility conditions, such as:

  • Low sperm count 
  • No sperm in the semen 
  • Weak movement of sperm or poor mobility
  • Abnormalities in sperm – size and shape

What are the steps involved in IVF in Turkey?

Before an IVF cycle begins, with patients undergo various screening tests and medical examinations to assess their eggs and sperm of the female and male partners. 

Some tests involved in the pre-treatment phase include:

  • Hormone evaluation –  This includes tests to assess thyroid function and other hormone levels to rule out endocrinology related conditions. 
  • Ovarian reserve test – This is to determine the quantity and quality of eggs of the woman partner. It involves testing the concentration of follicle-stimulating hormone (FSH), estradiol (estrogen) and anti-mullerian hormone in the blood. This is done during the first few days of the menstrual cycle. Results from these tests together with ultrasound of the ovaries help the IVF specialist determine how well the ovaries will respond to fertility medication.
  • Semen analysis – it might be done during the initial fertility evaluation or a semen sample might be taken and assessed before the start of an IVF treatment cycle.
  • Screening for infectious disease – Both the partner will be screened for infectious diseases such as HIV and other sexually transmitted diseases.
  • Uterine examination – The doctor will evaluate the inside of the uterus lining before starting the IVF procedure. It might include a sonohysterography, in which fluid is injected into the uterus through the cervix. The ultrasound images of the uterine cavity will help the doctor locate problems, if any. Instead of this test, a hysteroscopy might be recommended. A hysteroscope is a thin, flexible telescope lighted at one end. It is inserted through the cervix into the uterus for imaging.

A practice embryo transfer might also be done by some doctors. In this mock embryo transfer, the doctor will assess depth of uterine cavity and determine the technique that will be the most suitable for embryos transfer into the uterus.

The basic steps in an IVF procedure include the following:

  • Stimulation for maturation of follicles
  • Collecting or retrieval of the eggs
  • Collection of sperms sample 
  • Fertilization in the laboratory
  • Embryo transfer
  • Pregnancy test

There are mainly two protocols for IVF: 

Factors such as the woman’s age, ovarian reserve, blood hormone levels and body mass index are considered while determining the appropriate treatment protocol and the dose of medication for patients who will receive in vitro fertilization therapy.

Long-term protocol: The medications for induction of ovulation functions for around 10 to 12 days. The second part of the treatment starts when the patient begins menstruating, and the hormone therapy is continued for 8 to 10 days on average. This is to ensure maturation of eggs. After this, the eggs are picked up.

Short-term therapy protocols: In this, hormones for egg maturation starts from the second to third day of menstruation. The ovarian suppression hormones will be added to the treatment process within subsequent days to suppress the hormone secretion from ovaries.

Blood hormone levels will be analysed and the patients are monitored with vaginal ultrasound to keep a check on the follicles. When they reach the appropriate size, human chorionic gonadotropin is administered and eggs are picked up later on the same or next day. 

Ovulation stimulation

A drug, in the form of nasal spray or subcutaneous injection, will be given to the woman for about 2 weeks. This is to suppress the natural menstrual cycle and stimulate super ovulation. The fertility drugs usually contains the follicle stimulating hormone (FSH), a luteinizing hormone (LH) or a combination of both. This fertility hormone induces the production of more eggs than usual (super ovulation). Vaginal ultrasound might also be done to monitor the ovaries during the process.

Egg retrieval

After the super ovulation process, the eggs will be collected through follicular aspiration, a minor surgical procedure. In this, a thin needle is inserted through the vagina and guided into an ovary. The needle is connected to a suction device which helps collect the eggs from the ovary. This process is done for each ovary. Frozen or donated eggs may also be used for this process, as per the situation. 

Sperm sample

After collection of the eggs, male partner will be asked to provide a sperm sample. 

It can be retrieved through testicular biopsy or frozen sperm might be used. 

Fertilization 

The eggs and sperms are kept together in a petri dish and incubated in an environmentally controlled chamber. This would allow the sperm to penetrate the egg and fertilize it. Once fertilized, the egg will divide and develop into an embryo. Some doctor may recommend a pre-implantation genetic diagnosis (PGD) at this point to screen an embryo for genetic disorders. However, this is not done everywhere or in every case. 

Insemination can basically be done using two methods:

  • Conventional insemination: In this method, a healthy sperm sample is mixed with the mature eggs and incubated overnight.
  • Intracytoplasmic sperm injection (ICSI): During ICSI, a single sperm is directly injected into a mature egg. It is mostly used in the case of poor sperm quality or low quantity or if fertilization attempts in the prior IVF cycles have failed.

Assisted hatching is a technique in which a hole is made in the surrounding membrane, called zona pellucida just before the embryo transfer to help it hatch and implant. This enables the embryo implantation into the lining of the uterus. Generally, after five to six days for fertilization, the embryo hatches or separates from the surrounding membrane. 

It is commonly offered to the older woman, or those who have a history of multiple failed IVF attempts. Assisted hatching can also be benefit couples who are using eggs or embryos that were previously frozen as it might harden the surrounding membrane.

Embryo transfer

One or more embryos are selected and transferred into the uterus of the woman. The doctor might also administer progesterone or human chorionic gonadotrophin (hCG) to help the lining of the uterus for receiving the embryo.

More than one embryo is placed in the womb to increase the chances of one successful implantation. The doctor will discuss the number of embryos to be transferred as well as the risks of the procedure with the couple during the consultation. Usually, transfer of more than one embryo is only done when no ideal embryos are available.

Embryos are transferred after 2 to 5 days from egg retrieval, and it is performed using a thin catheter and ultrasound guidance. The transfer involves using a thin tube called catheter. It is inserted into the uterus through the vagina and retrieved when the embryo sticks to the lining of the womb. The healthy embryo will begin to grow here. This is a pain-free procedure and doesn’t usually involve the use of general anaesthesia. Patients are typically allowed to go home the same day following the embryo transfer.

Risks associated with IVF

There can be some side effects and complications due the fertility drugs used in the IVF process. Some possible side effects of such drugs are:

  • Nausea and vomiting
  • Difficulty in breathing
  • Hot flashes
  • Abdominal pain
  • Irritability or mood swings
  • Enlargement of the ovaries
  • Sleeplessness 
  • Bruising in the area where daily injections are given

Some potential complications related to IVF include:

  • Multiple births: IVF process may increase the chances of multiple births or possibility of twins/triplets/quadruplets if more than one embryo is transferred to the uterus. A woman pregnant with multiple babies is also at a higher risk of early labour and low birth weight in comparison to pregnancy with a single baby.
  • Ovarian hyperstimulation syndrome: This might occur due to injections of fertility drug, such as human chorionic gonadotropin (HCG), which help induce ovulation. Ovarian hyperstimulation syndrome is a condition in which the ovaries become swollen and painful.

Symptoms of this may include nausea, vomiting, diarrhea, mild abdominal pain and bloating. This may last for a week, but if the woman gets pregnant, they might go on for a few weeks. A more severe form of ovarian hyperstimulation syndrome that may cause rapid weight gain and shortness of breath, rarely occurs.

  • Risk of miscarriage: It has been reported that the rate of miscarriage in women who conceive though IVF (using fresh embryos) is similar to that of natural conception. However, the rate may increase with the age of the woman.
  • Complications associated with egg retrieval procedure: The process involves the use of an aspirating needle to collect eggs. This carries potential risk of bleeding, infection or damage to a blood vessel and other parts such as the bowel or bladder. Is sedation and general anesthesia is used, there is a possibility of allergic reaction to that.
Vanshika Rawat

Written By Vanshika Rawat

Vanshika Rawat is an experienced content developer. She is very knowledgeable in the field of science and healthcare and has worked under brilliant scientists during her higher education. Vanshika obtained her degrees in Masters in Science and Bachelors in Science (Microbiology with Hons.) from renowned institutions - Panjab University and University of Delhi.
Dr. Surbhi Suden

Verified By Dr. Surbhi Suden

Dr. Surbhi Suden is one of the founders of Lyfboat and a doctor with a renowned name in the Medical tourism industry. She has been working with international patients since 2008 and is a deeply committed professional with a long term vision of transforming the current healthcare scenarios.

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