Stem Cell Therapy for Cerebral Palsy in India

Last Modified: July 9, 2020  |   Created on: December 8, 2019
Cell Therapy

At a glance

  • The cost of stem cell therapy for cerebral palsy in India is USD 7500 – 12000
  • Cerebral palsy treatment in India by stem cells has shown improvement in functional abilities of children with cerebral palsy
  • There are different types of stem cell treatments depending on the source and type of stem cells. A stem cell has the potential to develop into all kinds of cell types and form different tissues. They also have the capability to renew themselves by dividing continuously. 
  • Autologous bone marrow derived stem cell transplant is a safe, feasible and effective method of treatment.
Stem Cell Cerebral Palsy

What is cerebral palsy?

Cerebral palsy is defined as a group of non-progressive brain malformation related disorders that affect movement and posture of the person. It is caused by damage to the developing brain during pregnancy or just after the baby’s birth, leading to a permanent physical condition. Cerebral palsy (CP) is one of the most common physical disabilities in children.

Children with cerebral palsy experience a range of movement problems including limited mobility, stiffness, weakness in limbs, shakiness, poor coordination and balance. It can cause other problems also, such as trouble with vision, hearing, speech, learning, epilepsy and cognitive thinking

Free personalized quote for stem cell therapy for CP child in india

(jpeg, jpg, doc, docx, pdf)

How many types of cerebral palsy are there?

Cerebral palsy (CP) is classified on the basis of:

Parts of the body that are affected

  • Quadriplegia all four limbs – both arms and both legs – are affected. The muscles of the trunk, face and mouth may also be involved
  • Hemiplegia one side of the body is affected, including the arm, leg, and trunk
  • Diplegia either both legs or both arms are affected
  • Monoplegia only an arm or a leg is affected

Pattern of movement

  • Spastic CP This is the most common cerebral palsy type. There is tightness or stiffness in the muscles as the damaged parts of the brain does not send proper messages to the muscles
  • Dyskinetic CP Involves abnormal involuntary movements or postures. It can be
    • Dystonic involves frequent twisting or repetitive movements and may alter between rigidity and flaccidity
    • Choreoathetoid there is an excessive uncontrolled (involuntary) movement particularly in the arms, hands and feet, and around the mouth. Leads to an abnormal posture.
  • Ataxic (or ataxia) CP this is the least common type of cerebral palsy. Children with ataxia display signs of unsteady and shaky movements or tremor along with problems with balance. It involves the cerebellum.
  • Mixed CP This involves different parts of the brain.

What are the causes of cerebral palsy?

Any kind of abnormality that occurs during brain development at the fetal stage (pregnancy), during birth or after birth, can lead to brain damage. There are a number of possible causes for brain damage that can result in cerebral palsy.

Before birth

  • Reduced blood or oxygen supply to the fetus
  • Infection to the mother such as cytomegalovirus, rubella, chickenpox or toxoplasmosis
  • A trauma or injury to the baby’s head during pregnancy
  • Congenital disorders such as Down’s Syndrome, Rett Syndrome

During birth

  • Asphyxia, which is lack of oxygen supply to the brain in case of a difficult birth
  • A brain infection such as meningitis
  • A serious head injury or trauma during suction delivery
  • Choking or nearly drowning, resulting in lack of oxygen to the brain
  • A serious drop in blood sugar level
  • A brain stroke due to sudden blockage of blood flow in the brain

After birth

  • A head injury due to an external trauma after birth, causing concussion or hemorrhage
  • A brain infection, such as encephalitis and meningitis

Risk factors:

  • Premature birth, i.e. before the 37th week of pregnancy. There is a higher risk of brain damage in babies who are born at 32 weeks or earlier as the fetus has not fully developed.
  • Baby born with low weight
  • Multiple pregnancy (or twins)
  • The mothers of 35 years of age or older
  • Unusually low blood pressure or high blood pressure of the mother
  • Exposure to drugs and alcohol, stress, heavy metals including mercury poisoning from fish during pregnancy

How can Lyfboat assist you in getting stem cell therapy for cerebral palsy in India?

World's Most Trusted Medical Advisory & Discount Platform

Lyfboat is a free advisory platform; we do not charge any fees from patients. In fact, we negotiate the price that Indian hospitals offer. In some cases we are able to reduce the cost by negotiating upto 20% of what Hospitals generally offer. We advise the best treatment from the top hospital/surgeon at best price.

What are the symptoms of cerebral palsy?

The signs of early of cerebral palsy can be observed in children of up to 1 year of age. Delayed development is usually the initial indication for cerebral palsy with problems performing basic motor functions such as sucking/feeding, neck control, sitting without support, rolling, crawling, grasping, and others.

Signs that can be observed in early age include:
When the child is less than 6 months in age:

  • Difficulty in head and neck control when picked up
  • Stiff legs that the baby crosses or scissors when picked up
  • Shakiness in the arms or legs
  • Trouble while sucking or feeding
  • Lack of muscle tone resulting in ‘floppy body’ or hypotonia. Abnormal muscle tone can also be observed in children with CP as stiff or rigid muscles

When the child is more than 6 months in age:

  • Poor head control when picked up
  • Use one side of the body more than other: reach with only one hand and keep the other one in a fist
  • Difficulty in rolling over without help
  • Difficulty in the movement of upper limbs and bringing them together
  • Crawling abnormally in a lopsided manner and dragging the other side of the body
  • Not able to sit or stand without support
  • Lack of response to own name
  • Doesn’t make babbling sounds and say single words such as ‘mama’ or ‘papa’.

Common physical symptoms of cerebral palsy include:

  • Deformities of the upper and lower limbs causing a bent wrist, closed fist or a rigid flexed elbow
  • Severe malnourishment with a floppy body, known as hypotonia
  • Difficulty in walking
  • Difficulty in breathing due to poor neck control and lowered immunity.
  • Sensory problems including poor vision and hearing, along with cognitive difficulties.

Other symptoms that may occur in some people include pain, hip displacement, non-ambulation, speech difficulties, epilepsy, behavioral changes, poor bladder control, disturbed sleep cycles, vision and hearing impairments as well as difficulty in swallowing.

What is a stem cell therapy?

Stem cell therapy is a cellular therapy that is a part of Regenerative Medicine, the futuristic field of medicine that deals with the process of repairing or regenerating the damaged tissues in the body.

Stem cells are primitive undifferentiated cells that have the capability to turn into all other cell types with specialized functions. They have two distinct properties that make them unique: multiply perpetually to form new cells (self-renewal) and differentiate into specialized cells, such as muscle cells, heart cells, brain cells and others.

Stem cell therapy exploits these unique properties of stem cells to treat certain medical conditions or prevent their further deterioration. There are mainly three types of stem cells that can be used:

  1. Embryonic stem cells (ESCs)

    are the cells found in a developing embryo that is 5-7 days old. These stem cells are pluripotent, i.e. they have the ability to convert into all other cell types present in the human body.

  2. Adult stem cells

    can be found in the tissues of all the humans. They have matured beyond the embryonic stage. These are multipotent cells that can differentiate into a limited number of specialized cells. The function of adult stem cells is to regenerate and repair the damaged tissues in the body. They can be obtained from certain bones, such as the bone marrow of the hip bone.

  3. Umbilical cord stem cells

    are obtained from the discarded umbilical cord after the birth of a baby. Mothers may donate the cord after delivery, which is then stored in Cord blood banks for future use.

For a stem cell therapy, cells may be obtained from two sources:

  1. Autologous

    Stem cells are taken from the patient’s own body for transplantation. The benefits of this method are – the risk of rejection is neutralized as self cells are used and chances of side effects are minimized

  2. Allogeneic

    The stem cells are obtained from another person (donor) and transplanted into the patient. The donor needs to be tested for genetic compatibility before extracting the cells for transplant. Umbilical cord stem cells can also be used for the type of transplant.

What are the conventional treatment options for cerebral palsy?

There is no known cure for cerebral palsy. Treatment strategies that are currently being used are aimed at managing the symptoms, preventing further complications, and promoting functional independence in the patient. An integrated approach with therapies and medications is conventionally followed to achieve these milestones.


  1. Physical therapy 
    Physical therapy or Physiotherapy is an important treatment method for managing cerebral palsy and physical disability associated with it. Exercises and muscle training can help enhance strength of muscles, flexibility, balance, prevent muscle contractures, relieve pain.
    All these contribute in increasing mobility and maximizing independence. The therapist uses special techniques such as stretching, gait training, and many other for this along with the appropriate aids and orthosis. They also help with managing the problems such as head and trunk control, rolling, and grasping.
  2. Occupational therapy
    It involves identifying the problems that the child is facing on a daily basis with normal tasks. The therapist helps the child gain some independence and enable them to carry out complex movements that are part of their daily tasks such as bathing, dressing, and other routine activities. They also educate the parents and caregivers about the possible modifications that can be done to support the child in functional activities.
  3. Speech and swallowing therapy
    Difficulty in speech and language development are the complications of cerebral palsy and many children experience trouble with making facial expressions and hand gestures. Speech therapy can help improve the oral motor skills and develop the speech and language skills in affected children. It involves teaching sign language or using special equipment such as computers for communication through pictures in children who cannot speak.
    In those who have hearing problems that causes delayed speech, the therapists provide guidance regarding hearing aids. There may also be problems with chewing and swallowing in children with cerebral palsy as their masticatory (chewing) muscles and pharyngeal (swallowing) muscles are weak. Swallowing difficulty can become life threatening because it can lead to severe choking or food entering the windpipe which leads to difficulty in breathing, or it may cause aspiration pneumonia of the lungs resulting in long term ailments and malnutrition. Speech therapists guide the children and caregivers through swallowing techniques, proper positioning and certain oro-motor exercises along with dietary changes (the consistency of food – soft/liquid/mashed). If the case is severe, a gastroenterologist may need to insert a feeding tube into the stomach through the nose or directly through the skin of the abdomen.


Medicines are given to lesser muscle tightness to manage difficult symptoms such as seizures, spasticity, pain, dystonia, drooling, improve functional ability, behavioural problems such as ADHD. 


Children with cerebral palsy may require orthopedic surgery to improve movement and provide pain relief. The corrective surgeries such as tendon release, corrective osteotomy and others are recommended for children with contractures of muscles causing limited joint movement, joint and bone deformities such as scoliosis or dislocation of hip.

How does stem cell therapy work for patients with cerebral palsy?

The currently available treatment options for cerebral palsy can help patients in managing symptoms to a limited level. They cannot repair the actual brain damage.

Cell therapy is a promising regenerative medicine technique that can be a potential treatment option for patients with cerebral palsy. It was earlier believed that brain damage that occurs during the birth of the child is irreversible. With recent advances in technology and stem cell research, a potential for repairing the damaged brain tissue with stem cell therapy has been observed. Stem cells can be obtained from various sources for cell therapy, such as umbilical cord and bone marrow mononuclear cells (BMMC).

Autologous bone marrow-derived stem cells offers a completely safe and effective method for treatment. Research has shown that the transplanted stem cells migrate to the damaged area in the brain and show reparative effects on the affected tissues to repair the damage. They release certain trophic mediators that reduces the effects of damage in the particular areas. The transplanted stem cells have the ability to differentiate into different types of cells of the nervous system such as oligodendrocytes, glial cells and others.

The mechanisms by which stem may help in tissue repair and regeneration include:-

  • Replace the damaged neural cells
  • Release growth factors to promote recovery
  • Prevent cell death of neurons
  • Establish new blood vessels
  • Regenerate neural cells by stimulating cell multiplication and integration
  • Help in establishing new neural maps in the brain to promote learning new functions.

These mechanisms can ultimately help in restoring activity in the affected area, which results in improvements of clinical symptoms and improving the overall quality of life of the patients.

The benefit of using autologous Bone Marrow Mononuclear cells (BM MNCs) is that there are no adverse side effects and the risk of immune rejection is eliminated. As these cells are obtained from the patient’s own body, there will be no ethical issues for the use of these stem cells.

What happens during a stem cell therapy?

Stem cells can be isolated from different sources:

  • Cord blood – The child’s own cord blood or from a donor cord blood bank can be used for transplantation
  • Bone marrow – the soft, spongy inner part of certain bones is rich in stem cells. The patient’s own cells (autologous) or from a related or unrelated matched donor (allogenic) can be used for the therapy. Bone marrow aspiration is used to extract the cells from the bone marrow with a thin needle.
  1. The cell isolated from bone marrow are transferred to a stem cell lab. There the centrifuge machine is used to separate stem cells from the heterogenous mixture of cells in the bone marrow aspirate.
  2. Then the doctor injects the purified stem cells into the child. The injection may be given intrathecally – into the space around the spinal cord to reach the cerebrospinal fluid (CSF).

Stem cell therapy is accompanied by a variety of rehabilitation programs that are designed to improve or manage specific symptoms.
For more details about Autologous Stem cell therapy procedure, read stem cell therapy in India.

What can be expected after the treatment?

Intrathecal injected autologous bone-marrow derived stem cell therapy is a completely safe and effective method of treatment for children with cerebral palsy.

The aim of this comprehensive treatment approach is to guide and support patients suffering from a debilitating condition like cerebral palsy. The patients have been able to reach a fixed stage after cell therapy where they show remarkable improvements in the symptoms. 

Patients diagnosed with cerebral palsy display a range of physical and mental symptoms such as problems with speech, balance, movement of upper limb and lower limb, muscle tone and ambulation. 

Stem cell therapy has shown an overall symptomatic improvement in 91% of the patients. 

The improvements range from mild, moderate to significant. Regular rehabilitation after cell therapy under expert supervision of a therapist has been shown to play an important role in the overall success and improvement of symptoms.

The improvements are attributed to the repair of the underlying brain damage. This can be objectively be seen on a PET CT scan of the brain in concert with improvement in functional and achievement milestones in patients. Stem cell therapy in combination with standard treatment enhances the extent of development and improves the quality of life of affected children.

Stem cell therapy for cerebral palsy in India

India is a one-stop destination for people seeking medical treatment with excellent quality and economical prices. Stem cell therapy for cerebral palsy in India is a safe and effective treatment approach for improving as well as managing the symptomatic problems of the condition. Many hospitals that offer stem cell therapy for CP child in India are internationally renowned and accredited for their hospitality services and quality of patient care. These medical facilities house the latest technology and advanced equipment required for delivering the best treatment. They provide a comprehensive rehabilitation program to ensure children with cerebral palsy can achieve the maximum benefits from the program.

The cost of stem cell therapy in India is remarkably lower than several other countries that provide the same treatment at 40-60% higher price. A person travelling from abroad can save a lot of money if they choose to undergo the procedure in India. And the best part is that the quality of treatment is at par with the best facilities of the world.

Frequently Asked Questions (FAQs) about Stem cell therapy for cerebral palsy in India

Q. What is the cost of Stem cell therapy for cerebral palsy in India?

The cost of stem cell therapy for cerebral palsy in India is USD 7500 – 12000.

Q. Is Stem Cell Therapy for Cerebral Palsy safe?

Cell therapy has proven to be a safe and effective treatment for children with cerebral palsy. Stem cells used in the therapy aim to renew the parts of brain damage and the results can be analyzed with PET CT scan for brain improvement. The use of autologous stem cells helps prevent complications such as graft rejection, infections, and others.

Q. Are there ethical concerns regarding cell therapy and research?

Bone marrow transplantation has been effectively used for the treatment of several disorders of blood and bone marrow, such as sickle cell anemia, thalassemia, and blood cancers. As Stem cell therapy for the treatment of cerebral palsy in India involves the use of autologous stem cells, it does not involve any major ethical concerns. Ethical problems majorly arise for the use of embryonic stem cells, which are not used in these therapies.

Q. How many cell transplantations are required?

After the first cell therapy, the doctor examines the growth and improvements to determine whether and how many transplantations are required for a patient. If the patient shows good improvement, they are further evaluated by the medical team, using a special PET CT Scan of the brain. A second cell treatment may be recommended by the doctor and it is usually done 3-6 months after the first therapy.

Q. How long will it take to see the results of the treatment?

Patients show most improvements within 3-6 months post stem cell treatment for cerebral palsy. Most children begin to show some instant improvements before they even get discharged. Sometimes, it may take several months or years to show significant improvement from the treatment.

Q. What treatment will follow after the therapy?

The treatment plan for Cerebral Palsy is not exactly the same for all the children. Greater improvement is shown after stem cell therapy for cerebral palsy when it is followed by subsequent rehabilitation. This may include traditional as well as unconventional approaches that are personalized for each child, after a thorough medical evaluation. Some therapies that are followed after stem cell treatment are physical therapy, occupational therapy, speech therapy, aquatic therapy, art-based therapies and group/motivational classes.

Q. Are there any side effects of cell therapy?

As with every kind of medical procedure, there can be some potential side effects after cell therapy. These include short-term and self-limiting side effects, such as a spinal headache that last 3-4 days along with vomiting, neck/back pain, mild rash or pain at the area of bone marrow aspiration or where the cell injection was given. There are chances of complications in children who have seizures, or a previous history of seizures or an abnormal EEG. The doctors will prescribe antiepileptic drugs to avoid these problems.

Vanshika Rawat

Written By Vanshika Rawat

Vanshika Rawat is an experienced content developer. She is very knowledgeable in the field of science and healthcare and has worked under brilliant scientists during her higher education. Vanshika obtained her degrees in Masters in Science and Bachelors in Science (Microbiology with Hons.) from renowned institutions - Panjab University and University of Delhi.

Happy Lyfboat Patients

Share on facebook
Share on google
Share on twitter
Share on whatsapp
Share on skype
Share on email
Send via Email

Six Simple Steps

Free Access to the Network

Our medical advisory platform automatically sends your medical query to our network of expert Doctors, working only at top internationally accredited Hospitals.

Direct Communication

You and the medical providers communicate directly via email or your online patient account; our case managers are always available to help you with this.

Get Verified Quotations

You receive medical opinions and cost estimates within 24 to 48 hours via email and your online patient account.

Compare Quotes & Advices

Lyfboat empowers you to compare the medical opinions, and discuss the options with our very own doctors who help answer your questions, and guide you in making informed decisions on the best treatment option.

Get Discounted Costs

We negotiate your final costs, explore available discount offers, and we handle all your logistics including travel, accommodation, transport, and medical co-ordination.

Return Home Fit

Get cured, pay hospital after treatment and return home safe. Our care team is available throughout your journey to good health!

Help us improve this Page

5 average based on 65 reviews.

Free Enquiry