The Changing Face of Blood Cancer Treatment in India: Innovations and Challenges

Last Modified: April 11, 2024  |   Created on: December 7, 2021
Blood Cancer

America, a country of roughly 33 million people, performs 33,000 bone marrow transplants. In India, a country of 1.4 billion, we are still at 3,000. – Dr. Rahul Bhargava, The Economic Times (2021)

Blood-cancer-treatment-ayushman-bharat

Hematologic cancer, the cancer of blood cells, is still a big challenge in 2021. According to WHO, more than one million people worldwide suffered from one or the other type of blood cancer in 2020 alone. The numbers tell us that blood cancer affects many people, including the very young and the very old. 

The survival rate among those affected has seen a considerable rise, thanks to the advancements in medicine and technology. Still, thousands of people are expected to lose their lives to blood cancer in the next few years.

Blood cancers are challenging to treat and need a personalized treatment approach to attend to the patient’s needs. Many developed countries like the USA have positioned themselves for success with breakthroughs in blood cancer treatment and medicine.

However, for countries like India who have established leadership in the field of medicine, the work is far from finished.

And, it is obvious for us to ask why?

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Blood Cancer Treatment in India

The private healthcare sector in India is at its peak of success. Presently, the country has established a vast network of hospitals that boast an unfaltering infrastructure, the most advanced medical technologies, a pool of experienced doctors, and accreditations from some of the most prestigious names in the industry. With such medical advancements and immediate resources, effective blood cancer treatment in India is no longer a dream. 

Every year, the country welcomes a huge influx of international patients seeking quick, quality, and affordable treatment in India. Depending on the patient’s condition and the diagnosis by the doctor, a patient can undergo one of the following blood cancer treatments in India. 

1. Chemotherapy

Chemotherapy is not an alien concept anymore. In fact, the majority of people feel that chemotherapy is the only possible treatment for any cancer. While that may not be entirely true, chemotherapy is indeed the go-to treatment option in treating cancer. Chemotherapy requires the introduction of an anti-cancer drug into the patient’s body. It can be done intravenously or orally. The anti-cancer drug targets the cancer cells and halts their growth. 

  • Average duration: 4-5 months
  • Cost: 1,200 – 3,000 USD/cycle
  • Common risks: Fatigue, Nausea, Hair loss
 

2. Radiation therapy

Radiation therapy may or may not be combined with chemotherapy. It uses streams of high energy to kill the cancerous cells. The energy can be supplied through an external machine or an internal solid or liquid source. The external radiation therapy targets specific areas and doesn’t affect the other organs. On the other hand, internal radiation therapy damages the DNA of the cancer cells and may target normal and functional cells. Therefore, the blood count of patients undergoing the latter is continuously monitored, and they may even require regular blood transfusions.

  • Average duration: 2 to 5 months 
  • Cost: 5000 – 30,000 USD
  • Common risks: Fatigue, Nausea, Hair loss
 

3. Target therapy

As the name suggests, this type of therapy is designed to target cancer cells. This means that the healthy and functional cells are not affected during the procedure. Malignant cells express unique surface as well as intrinsic proteins, also known as antigens. Scientists and researchers have developed antibodies and small drug molecules specific to these antibodies. As soon as these antibodies recognize their target antigens, they trigger an immune response, block the signaling pathways, and stimulate the formation of other inhibitory proteins. All these events lead to the death of the cancer cell, which is referred to as necrosis. 

  • Average duration: 2 to 5 months 
  • Average Cost: 25,000 USD
  • Common risks: Diarrhea, Liver problems, Blood clotting, High Blood pressure, etc.
 

4. Bone marrow transplant

A bone marrow transplant is performed to replace diseased and non-functional parts of the bone marrow with new and healthy stem cells. Bone marrow transplant in India can be of two types:

Autologous BMTAllogenic BMT
The donor and recipient of stem cells is the same individualThe donor and recipient of stem cells are two different people. They may be related or unrelated.
Minimal to no chances of immune rejectionThere is a significant chance of immune rejection
Risk of developing cancer after BMT is highRisk of developing cancer after BMT is low
Some stem cells can be cancerousAll stem cells will be cancer free
No need for immunosuppressionRequires immunosuppression
Time for engraftment is 7-10 daysTime for engraftment is 2-4 weeks
  • Average duration: 2 to 5 months 
  • Average Cost: 15,000 – 22,000 USD
  • Common risks: Immune-rejection, Graft-vs-host-disease 
 

5. Immunotherapy

Our immune system is a complex interaction of proteins and cells. Immunotherapy undertakes the task of activating the immune system so that the basic course of action can take place. Currently, blood cancer hospitals in India offer the following categories:

  1. Cytokine therapy – Promote the formation of interferons and interleukin by the WBC’s that cause cell impairment and death. 
  2. Gene-therapy- It involves the transmission of a genetically manipulated viral vector into the DNA of the cancer cell. These block the normal cell functions, eventually causing cell death. 
  3. Immunomodulators – These specialized substances orchestrate the interaction between different cells to initiate the necessary immune response. 
  • Average duration: 2 to 5 months 
  • Common risks: Fatigue, Nausea, Weight-loss, Decreased appetite, etc. 

With an enormous population that continues to rise every day and tons of international patients flocking the country all around the year, why is India still behind the USA in terms of performing procedures like bone marrow transplants or chemotherapy? 

Here’s an answer to the why. 

Three big challenges concerning blood cancer treatment in India

“America, a country of roughly 33 million people, performs 33,000 bone marrow transplants. In India, a country of 1.4 billion, we are still at 3,000.”

In a recent interview with a leading newspaper, Dr. Rahul Bhargava has addressed the gap between blood cancer treatment in India and the USA. Dr. Rahul Bhargava concludes that the country faces primarily three challenges when it comes to having effective and timely treatment, which includes:

Acceptance

Dr. Bhargava, a leading hemato-oncologist at the Fortis Memorial research institute, has seen people equate the condition with a death sentence. So, the initial problem lies in the acceptance of the disease. Myths and misconceptions regarding chemotherapy continue to haunt people. It refrains them from getting necessary treatment, and most importantly, treatment at the right time. However, with the current breakthroughs in science, India has developed a strong leadership across research and medicine. Therefore, chemotherapy is no longer something that a patient should fear. 

Diagnosis

To date, most blood cancers in India are detected at the fourth stage, where treatment often fails. Dr. Bhargava is quick to present the fact that it’s not just the lack of awareness among people but the inability of the present healthcare system to offer a correct diagnosis. Specifically, the rural parts of India face an absence of a holistic healthcare system that can help them identify the signs and symptoms of the disease at an initial stage. The government has made its share of efforts by setting up digital health centers pan India. Top government and public hospitals in India now offer facilities like digital slide scanners that detect blood cancer in a timely fashion. Dr. Bhargava believes that investing in more such diagnostic facilities is the best way to tackle this disease. 

Affordable treatment

Last but the biggest challenge the Indian population faces is low access to affordable healthcare and treatment. A bone marrow transplant in India can cost somewhere around 15,000 USD to 22,000 USD. This cost is certainly not affordable for a majority of Indians. According to Dr. Bhargava, if the government includes bone marrow transplant procedures as a part of its recent schemes like Ayushman Bharat, the treatment would become available at a fraction of the original costs. Establishing public-private relationships is the ultimate way to go! 

How can Lyfboat assist you in getting Blood Cancer treatment in India?

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Lyfboat is a free advisory platform; we do not charge any fees from patients. In fact, we negotiate the price that Indian hospitals offer. In some cases we are able to reduce the cost by negotiating upto 20% of what Hospitals generally offer. We advise the best treatment from the top hospital/surgeon at best price.

Research & Innovation in Blood Cancer Treatment in India

Innovation and research in blood cancer treatment are accelerating at a rapid rate. As of 2017, the U.S. Food and Drug Administration (FDA) has approved almost 53 therapies targeting different categories of lymphomas, leukemias, and myelomas. Many of these therapies have been advanced in premier research institutions across India. The next few years are expected to be as groundbreaking and productive as the last decade.

  • CAR-T cell therapy 

CAR-T cell therapy has been a great source of excitement for researchers across the world and has shown great results for patients with Acute lymphoid leukemia (ALL) and Large B-cell lymphoma. The procedure involves engineering and reprogramming the patient’s T cells to express unique protein receptors called Chimeric Antigen Receptors. CAR-T cells are highly-specific to the antigens present on a cancerous cell, increasing the chances of cell recognition and apoptosis. Furthermore, with new advances in “off-the-shelf immunotherapy,” allogeneic CAR-T therapy would also become a possible treatment option. 

  • Precision Medicine 

As mentioned before, chemotherapy continues to dominate almost all forms of Cancer. However, different types of conditions call for a personalized treatment plan. Therefore, there is a need to develop a treatment that goes beyond the idea of ‘one-size-fits-all.’ That’s where precision medicine steps in. Patients with Acute myeloid leukemia (AML) and Chronic lymphocytic leukemia (CLL) are now given medication and therapy as per their molecular profile. This trend has shown great promise in the role of precision medicine in blood cancer treatment. 

  • Advancements in Pediatric Cancer treatment

Active research in pediatric blood cancer treatment is long pending. Especially, children suffering from Acute lymphocytic leukemia are still given treatment according to the protocols set almost three decades ago. Although many children are able to recover from the disease with chemotherapy, the side effects of the treatment stay with them throughout their lives. There are many independent as well as government-aided organizations that have taken upon them to run clinical trials for precision medicine targeting children.

At the end of the day, scientific progress means nothing if the patient doesn’t have access to the treatment. Furthermore, awareness about the signs and symptoms of the disease among people is equally important. There is a strong need to invest in game-changing science and take active steps to promote timely and effective diagnosis in blood cancer treatment, helping millions living today and diagnosed tomorrow!

Simran Bahia

Written By Simran Bahia

Simran Bahia is an experienced content writer with extensive research experience in Immunology and Reproductive Biology. Simran received her Bachelors in Life Sciences from Delhi University, followed by a Master's in Immunology from the Amity Institute of Virology and Immunology. Combining her love for science and writing, Simran enjoys putting a spin on standard methods of medical writing.
Dr. Surbhi Suden

Verified By Dr. Surbhi Suden

Dr. Surbhi Suden is one of the founders of Lyfboat and a doctor with a renowned name in the Medical tourism industry. She has been working with international patients since 2008 and is a deeply committed professional with a long term vision of transforming the current healthcare scenarios.

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